Desmoplakin is a protein found in people that are amplified by the DSP gene. Desmoplakin is an important part of desmosome constructions found generally in coronary muscle and epidermal cells. Their work is to keep the structure intact while adjoining cell connections.
Mutations taking place at Desmoplakin have been proven to play a part in the process of dilated cardiomyopathy, right ventricular cardiomyopathy, and paraneoplastic pemphigus. Desmoplakin knew as DSP has a high molecular weight in the family of the desmosomes protein. You can buy a high-quality Desmoplakin antibody to measure Desmoplakin.
In a cardiac muscle, Desmoplakin is located near intercalated disks which automatically link cardiac cells so that they can operate in a coordinated syncytial structure. It's involved in the formation of the desmosomal cadherin-plakoglobin mixture formed in different plasma membrane domains and at the anchoring of intermediate filaments inside the desmosomes.
Desmoplakin mutations are related to Keratoderma and cardiomyopathy mostly. Desmosomes are intercellular junctions that are responsible to link cells. Desmoplakin antibody has been demonstrated as a transglutaminase substrate in vitro. It implies that it might participate in cell adhesion at the intra-epidermal degree.
Desmosomes are characterized by two kinds of interaction with other cellular structures. This antibody is valid for western blotting using whole cell lysates in it. Primarily, they form membrane anchorage websites for intermediate-size filaments, and second, a particular membrane interacts with a corresponding domain name of the plasma membrane of an adjoining cell.